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Vaccination 

There are two vaccines available to prevent monkeypox and other orthopox viruses:

  • JYNNEOS, a replication-deficient live Vaccinia virus vaccine, licensed in 2019, and
  • ACAM2000, a replication-competent live Vaccinia virus vaccine.

Due to the safety profile of the two vaccines, JYNNEOS is preferred over ACAM2000 for monkeypox prevention. Persons at risk for occupational exposure to monkeypox will be offered vaccination. 

Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 | MMWR (cdc.gov)

Orthopoxvirus vaccines are not available through private markets and are currently only indicated for special populations for pre-and-post-exposure prophylaxis. Providers must consult with NDDoH (701-328-2378) to receive these vaccines.

To find out more about who is eligible to receive vaccine and where vaccine is available in North Dakota, use the Monkeypox Vaccine Locator.