Human Rabies Vaccine Information
Postexposure rabies vaccination, also known as postexposure prophylaxis (PEP), for someone who has never been vaccinated against rabies consists of one dose of human rabies immune globulin (HRIG) and four doses of the rabies vaccine.
On the first day of treatment (day 0), a person will receive HRIG and the first dose of the rabies vaccine. HRIG is synthesized by separating antibodies (immunoglobulins) specific for rabies from the plasma of people already vaccinated against rabies. HRIG should be administered around the area of the bite/injury to immediately provide passive immunity to the rabies virus. This should be done after the area has been properly cleaned by thoroughly flushing and washing with soap and water for a minimum of 15 minutes. The rabies vaccine must only be given in the deltoid muscle of adults or in the anterolateral thigh of young children. It is very important that the vaccine is administered to a site distant from the area that was infiltrated with HRIG to avoid decreasing the effectiveness of the immunoglobulin (e.g., if a person was bitten on the right hand, HRIG would be administered to the right hand and the vaccine would be given in the left deltoid).
Subsequent rabies vaccinations will be given on days 3, 7, and 14.
A patient who is immunocompromised (e.g., due to chemotherapy or radiation treatment, HIV or AIDS, a genetic disorder, etc.) would receive a fifth rabies vaccine on day 28.
PEP for someone who has previously been vaccinated against rabies is similar, but the person would not receive HRIG and only two doses of the rabies vaccine would be given as boosters (one on day 0 and one on day 3).
- Patient Assistance Programs for Uninsured or Underinsured Patients (PDF)
- Recommendations of the Advisory Committee on Immunization Practices for Rabies Prevention, 2008(PDF)
- Use of a Reduced (4-dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies, 2010 (PDF)
- Rabies Vaccines and Immunoglobulin Available in the United States
Human Rabies Vaccine and HRIG Availability in North Dakota
If your healthcare facility wishes to be included on this list, please contact the Division of Disease Control at 800.472.2180.
Domestic Animal Rabies Vaccination in North Dakota
Vaccination laws for domestic animals vary by location throughout the state. Please contact your veterinarian for information on vaccination regulations in your area.
For information on animal movement and importation requirements in North Dakota, please visit the North Dakota Department of Agriculture, Animal Health Division's website.